Retinal Advanced is dual-phase nighttime facial serum that helps to accelerate skin renewal for a more youthful appearance. Formulated with retinaldehyde and two high-performance ingredients with retinol-like properties which promote a gentle skin surface turnover, improving texture and visibly reducing fine lines and wrinkles. Retinal Advanced, with Melatonin and Soothing Complex, including Niacinamide, helps to smoothly renew the skin while helping to minimize the sensation of dryness. Key Ingredients: Retinaldehyde - A derivative of vitamin A, it supports collagen production and skin renewal, while also helping unify complexion. Melatonin - When applied topically, it acts as an indirect antioxidant, stimulating natural defenses against harmful free radicals. Soothing Complex - Ultra-soothing ingredients, including niacinamide, work together to hydrate, calm and revitalize the skin. Bakuchiol - Of natural origin, it demonstrates retinol-like properties, gently helping restore elasticity and firmness. Dermstore has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy ISDIN products with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket. Eligible for HSA/FSA with a letter of medical necessity at checkout. From dermatologist-recommended treatments to solutions for chronic skin conditions like acne, eczema, and rosacea, these products are both effective and eligible. | ISDIN Isdinceutics Retinal Advanced Night Serum, 50 ml | Dermstore